Atypical antidepressants are the “other” antidepressants that may be prescribed to you if you don’t respond to other categories of antidepressants.
The Mayo Clinic explains that atypical antidepressants ease depression by impacting chemical messengers -neurotransmitters - used to communicate between brain cells. Since atypical antidepressants are drugs that don’t clearly fit into a single category, each one works differently and on different neurotransmitters.
Examples include (brand name italicized):
- Bupropion (Wellbutrin, Forfivo, Aplenzin)
- Mirtazapine (Remeron)
- Vortioxetine (Trintellix)
Each drug has its own side effects but most atypical antidepressants include the following:
- Dry mouth
 Mayo Clinic Staff. “Atypical Antidepressants.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 25 June 2016, www.mayoclinic.org/diseases-conditions/depression/in-depth/atypical-antidepressants/art-20048208.